ABSTRACT
@#BACKGROUND. The Mongolian traditional medicine Anar-5 is excellent for weak digestion and helps with stomach irritation, loss of appetite, and resulting body weakness. Anar-5 blends punicagranatum, cinnamomum cassia presl, piper longum, cardamom and alpiniaofficinarum. We are establish an experimental animal of chronic gastritis to investigate the effect of traditional medicine Anar-5 on rats gastric mucosa. Methods: In this study, the protective effect preparation in sixty five healthy, male wistar rats were treated with intragastric administration of ammonia water 0.1%. To rats in three experiments for 2 week, 4 week, and 6wk, gastric tissues were examined histopathologically for atrophic changes and blood’s gastrin produced by preparation treatment. Results: After the treatment of animals blood’s gastrin was significantly different from that in control group (p<0.05), and the gastric mucosal inflammation was infiltration of inflammatory cells, decreased thickness of lamina propria. Conclusion: Treatment with preparation from Anar-5 protectived by the chronic gastritis and gastric atrophy.
ABSTRACT
The Mongolian plants considered to possess medicinal properties may contain novel compounds since they are exposed to severe conditions; such plants could become good candidates for modern drug discovery programs. Daurian Thermopsis (Thermopsis lanceolata R.Br.= Th.dahurica Czefr.), Gobian Thyme (Thymus gobicus Tschern.) and Mogilev Mallow (Malva mohileviensis Downer) are separately used as mucolytic and anti-inflammatory treatment in non-conventional medicine. Therefore, weprepared extract of these herbals compound called as a Tetima and to evaluate it’s acute toxicity. It isimportant to produce mucolytic effective new pharmaceutical preparation used for upper and lowerrespiratory tract inflammatory disease.Tetima herbal compound extract was prepared in ethanol, the ratio of herbals to ethanol was 1:10. Healthy 25 white albino mice (male weighing between 17-30 gram) used in this study. They were kept in large airy cages in groups of 5 animals per cage with free access to food and water. Five doses (8-20 g/kg) were then chosen for the determination of intraperitoneal LD50 in mice and given to five groups of albino mice. The animals were observed for first 2 hours and then at 6th and 24th hour for any toxicsymptoms. After 24 hours, the number of deceased mice was counted in each group. The percentage of animals that died at each dose level was transformed and then LD50 determined by the methods of Karber and Pershin.G.N.The LD50 of Tetima herbal compound in mice was determined to be 14.3 g/kg after intraperitonealinjection. There was no difference occurred between Karber and Pershin methods to evaluate acute toxicity. In the animals receiving intraperitoneal injection, the abdominal muscle contractions and ataxia was observed, which persisted for few hours. At the 6th hour they were drowsy and less responsive. The severity of these effects was related to the level of dose. However, at 24th hour most of the survivors had recovered from these symptoms.Tetima herbal compound extract is a relatively safe, particularly when given intraperitoneal inject toexperimental animals.
ABSTRACT
PUR POSE The aim of the present study was to determine the effective dose of Carbamazepine . according to the serum level concentration. ° METHODS 20 patients with symptomatic focal epilepsy: 10 males and 10 females included in the study. The average age was 3I.8± 8.9 (range 16-50 years).The mean duration of partial seizure was 11.4 ±5.8 years. All patients were using inappropriate doses of Carbamazepine and most of patients were taking it irregularly. Patients were follow- upped during 3 months. Initial dose of treatment was 9.4 ± 2.2 mg/kg. Pharmacokinetic analysis was performed by ABBOTT TDXFLX immunofluorescence autoanalyser in the Laboratory department of the Central Clinical Hospital. The blood samples were collected from patients in the morning before taking the morning dose and after 2 hours. RESULTS Therapeutic effective serum level of Carbamazepine in 8 seizure free patients (40%) was 8.25 ±2.11 ng/ml (range 6.89- 10.77), daily average dose I0.63±2.57mg/ kg. Adverse effects were observed in 7 patients. Average side effect dose was 14.0 ±3.3 mg/kg and 1275±125 mg (p<00l), serum level was 9.4±2.2 ng/ml. One patient had skin rash, drowsiness, ataxia, tremor, diplopia, vomiting and headache. However those syndromes were disappeared when dose of the drug was reduced. Adverse effects registration was performed. Key words: carbamazepine. therapeutic drug monitoring, partial CONCLUSIONS seizure our results clearly demonstrates that is no difference of the response of Carbamazepine between Mongolian patients and patients from other Asian and Western country. The study has been approved at